Loss of Hand Movement
One of the notable symptoms of Rett Syndrome is the progressive loss of hand movement in children between the ages of 1 and 4. During this stage, affected children gradually lose the ability to use their hands. Additionally, they may exhibit other repetitive hand movements commonly associated with autistic conditions, including hand-wringing, hand washing, clapping, tapping, or clasping. It is important to note that these hand movements may persist throughout the teenage years and into adulthood. Although there may be slight improvements in these physical manifestations over time, individuals with Rett Syndrome will typically experience them for the rest of their lives.
Decline in Language Abilities
Children diagnosed with Rett Syndrome commonly experience a decline in their language skills between the ages of 1 and 4. This marks the onset of a communication shutdown within their bodies. The MECP2 gene, which plays a crucial role in various aspects of their cognitive, sensory, emotional, motor, and autonomic functions, directly impacts their brain and their capability to articulate sounds using their mouths and vocal cords.
Over time, individuals with Rett syndrome may develop certain non-verbal communication skills as an alternative means of expressing themselves.