Borna Disease Virus and Its Potential Link to Obesity and Neuropsychiatric Disorders
The Borna disease virus (BDV) is known to impact various warm-blooded animals and has been found to potentially contribute to the development of obesity. In rodents, studies have shown that the virus attacks the central nervous system, leading to weight gain and obesity. However, the extent to which BDV affects humans is still a subject of debate among experts.
Several studies have suggested a potential connection between the Borna disease virus and certain neuropsychiatric disorders, including depression, schizophrenia, and bipolar disorder. Researchers have found links between the presence of BDV antibodies in individuals with these conditions, suggesting a possible association between the virus and the development or exacerbation of these mental health conditions.
While further research is needed to establish a definitive link between the Borna disease virus and obesity or neuropsychiatric disorders in humans, these findings highlight the importance of continued investigation into the potential impact of BDV on human health. Understanding the mechanisms through which the virus may affect the central nervous system and its potential implications for weight regulation and mental health could pave the way for new treatment strategies and interventions.
SMAM-1: The Avian Adenovirus Linked to Obesity
In the 1970s, a mysterious disease caused a significant number of chicken deaths in India. Extensive research by virus experts led to the discovery of an avian adenovirus named SMAM-1, which was identified as the culprit. Not only did this virus compromise the chickens’ immune function, but it also induced an abnormal increase in body fat, irrespective of their food intake. Interestingly, this increase in body fat did not always correspond with an increase in overall weight. The virus was essentially manipulating the chicken’s body to store fat at the expense of lean mass.
SMAM-1 made history as the first virus associated with human obesity. A study revealed that individuals with SMAM-1 antibodies exhibited higher body weight and body mass index compared to those without the antibodies. However, it remains unclear whether the human subjects developed antibodies specifically to the avian adenovirus SMAM-1 or to a similar adenovirus that affects humans.