Who is Affected by Dupuytren’s Contracture?
Dupuytren’s contracture primarily affects men over the age of 50 who are of Northern European descent, which has led to its nickname, Viking’s disease. While this condition is more prevalent in certain groups, several other factors can increase the likelihood of developing Dupuytren’s contracture. Smoking and excessive alcohol consumption are known to raise the risk of this condition. Additionally, individuals with a lower than average body mass index (BMI) and those who engage in manual labor are also more susceptible to Dupuytren’s contracture. Certain medications used to treat epilepsy, diabetes, liver disease, thyroid problems, elevated cholesterol, and previous hand injuries can also contribute to an increased risk of developing this condition.
Inheritance
Dupuytren’s contracture, the most common inherited connective tissue disorder, shows a strong correlation with family history. Individuals with a family background of this condition have a 60 to 70% higher likelihood of developing it themselves. However, the exact cause of Dupuytren’s contracture remains unknown, making it impossible to predict which specific family members will be affected. Interestingly, gene markers associated with the disorder may also appear in individuals who will never experience any connective tissue problems. In rare cases, Dupuytren’s contracture may manifest in individuals with no family history, although these instances generally tend to be less severe compared to the hereditary form.