Drug-induced Brugada Syndrome
Drug-induced Brugada Syndrome is a condition that can be triggered by certain types of medications. Research has shown that the misuse or overuse of tricyclic antidepressants can lead to an antiarrhythmic action, potentially inducing Brugada Syndrome. Similarly, high doses of certain anesthetics have been found to reveal the syndrome. Interestingly, a study found that Brugada Syndrome can also be induced by first-generation antihistamines, which are commonly known for causing sedation. Lastly, it has been discovered that cocaine, due to its strong sodium channel blocking effects, can provoke a fatal cardiac event in individuals susceptible to Brugada Syndrome.
Fever-induced Brugada Syndrome
Brugada syndrome is a complex condition that can be difficult to diagnose. Research indicates that only one out of every three electrocardiograms (ECGs) will show a Brugada pattern, while another third will be considered normal. However, in cases of fever, individuals who may have undiagnosed Brugada syndrome are more likely to experience symptoms. There are a couple of reasons for this. Firstly, during an illness, the dysfunctional sodium channel in the heart is further aggravated, making it more detectable on the ECG. Secondly, having a fever can trigger abnormal heart rhythms, or arrhythmias. Although fever-induced Brugada syndrome is still being investigated, its prevalence and rarity have not yet been determined by scientists.