Malignant fibrous histiocytomas (MFH) are a form of malignant tumors, specifically sarcomas, that develop within the soft tissues or bones. While they are the most commonly diagnosed sarcomas in soft tissues, their occurrence in bones is relatively rare. In 2002, the World Health Organization renamed this type of tumor to undifferentiated pleomorphic sarcoma due to the lack of knowledge about the exact cell type from which it originates. However, medical professionals and researchers still commonly refer to this condition as malignant fibrous histiocytoma or MFH.
Symptoms
Malignant fibrous histiocytoma (MFH) is characterized by the presence of a palpable lump or mass. These tumors commonly develop in the limbs, hands, or feet. They have a tendency to grow rapidly and might exhibit redness and warmth upon touch. While some MFH tumors are associated with pain, others may be completely asymptomatic.
Causes of Malignant Fibrous Histiocytomas
Malignant fibrous histiocytomas (MFH) have no specific known cause, although certain related conditions have been identified by researchers. It has been observed that individuals who have received radiotherapy for a different type of tumor may have an increased risk of developing MFH. Additionally, there may be a connection between Paget’s syndrome, a condition that affects the growth of bone cells, and the development of MFH tumors. Furthermore, individuals with a history of other types of sarcoma, such as Werner syndrome or Gardner syndrome, are more likely to develop MFH tumors.