Childhood Hypophosphatasia (HPP): Symptoms and Effects
Childhood hypophosphatasia, also known as HPP, is a condition that exhibits a wide range of variability. Physicians may categorize it as either mild or severe, depending on the specific symptoms experienced by the child. One of the most prominent signs of childhood hypophosphatasia is the premature loss of baby teeth. Children affected by this condition may begin losing their deciduous teeth before the age of five. In some cases, all or several of their baby teeth may be affected.
In addition to tooth loss, children with childhood hypophosphatasia may also develop bone deformities and experience symptoms similar to those of rickets. These skeletal issues can lead to delays in walking and cause significant muscle weakness or pain. In more severe cases, the cranial bones may fuse prematurely, resulting in increased cranial pressure.
Hypophosphatasia (HPP) in Adults
Adult hypophosphatasia (HPP) shares similar symptoms to childhood HPP. Some adults may notice the premature loss of their adult teeth. Osteomalacia, which is the softening of the bones, is also commonly observed in individuals with this condition. As a result, stress fractures in the metatarsals of the feet are more likely to occur. Pseudofractures may also develop in the thighs. Unfortunately, the body’s natural healing process is hindered, leading to severe and chronic pain in those with adult HPP. Additionally, the accumulation of calcium crystals near joints can cause damage and contribute to pain in affected individuals.