Non-Neurological Symptoms of Leigh’s Disease
Leigh’s disease is known for its neurological symptoms, but it can also manifest non-neurological symptoms. These symptoms include episodes of vomiting, diarrhea, difficulty swallowing, and seizures. Additionally, individuals with Leigh’s disease may experience an increase in irritability and a loss of appetite.
As the disease progresses, it can affect various bodily systems. The respiratory system may start to shut down, leading to breathing difficulties. Leigh’s disease can also have an impact on cardiovascular and renal function, causing additional complications.
In some cases, hormonal activity can be affected, resulting in particular physical features such as short stature. These non-neurological symptoms, combined with the neurological symptoms, contribute to the complexity of Leigh’s disease and its overall impact on individuals affected by it.
Diagnosis
When diagnosing Leigh’s disease, a doctor will conduct several tests to evaluate the presence of elevated lactate levels and changes in nervous system tissue. The physician may use imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT) scan to examine the brain for signs of brain stem diseases and associated characteristics. These characteristics may include the presence of decaying skin cells, often in the form of lesions, on the brain. Furthermore, recent studies propose the inclusion of tests for mitochondrial dysfunction in the diagnostic process.