Pellagra: Symptoms and Causes
Pellagra is a condition that arises due to an imbalance in the body’s hormone levels caused by the overproduction of serotonin, a primary chemical secreted by carcinoid tumors. These tumors lead to a significant increase in serotonin production, which disrupts the normal functioning of the body.
One of the prominent symptoms of pellagra is diarrhea, which can occur frequently and persistently. Additionally, individuals with pellagra may experience inflammation of the skin and cognitive impairment, often leading to dementia.
Furthermore, pellagra can affect a person’s behavior, causing increased aggression and heightened sensitivity to sunlight. Hair loss and sleep disturbances are also common indications of this condition.
Overall, pellagra is a consequence of the hormonal imbalance triggered by carcinoid tumors, leading to various distressing symptoms affecting the digestive system, skin, cognition, and behavior.
Heart Problems
When a person has an advanced carcinoid tumor, it can cause lesions in the heart valves, leading to a condition known as carcinoid heart disease. This serious condition is believed to be caused by the excessive production of vasoactive chemicals by the tumor. Typically, carcinoid heart disease begins in the valves on the right side of the heart and can eventually result in right-sided heart failure. In such cases, doctors may recommend valve replacement surgery as a treatment option.