Fever: A Sign of Drug-Induced Hypersensitivity Syndrome (DIHS)
In cases of severe allergic reactions, individuals may experience drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS). This syndrome typically manifests 7-14 days after initiating the use of a particular drug and poses a life-threatening risk as it affects multiple internal organs simultaneously. Although DIHS is relatively rare, it is commonly associated with the use of sulfonamide antibiotics.
Fever is a prominent symptom of DIHS and serves as an indicator of a severe reaction taking place within the body.
Organ Dysfunction in Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS)
Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS) is a condition that often leads to the dysfunction of multiple organs, primarily affecting the skin, liver, and hematopoietic system, which includes the bone marrow, spleen, thymus, and lymph nodes. If left untreated, DIHS can progress to acute liver failure, potentially requiring a liver transplant for management. The treatment approach for DIHS typically involves the administration of corticosteroids during the acute phase, while medications for hypothyroidism or diabetes mellitus may be required in the chronic phase.