Empty Sella Syndrome and Pituitary Function

Symptoms of Empty Sella Syndrome

Empty sella syndrome can lead to a variety of symptoms, with the severity and presence of symptoms depending on the underlying cause. While many individuals with this condition may not display any symptoms, there are instances where certain effects may arise. These include an increase in pressure within the skull, which can result in the leakage of cerebrospinal fluid from the nose and potentially lead to changes in vision. It is important to note that the function of the pituitary gland is typically unaffected in most cases of empty sella syndrome. However, those individuals who have developed secondary empty sella syndrome due to either a pituitary tumor or trauma are more likely to experience these symptoms.


Pituitary Function and Empty Sella Syndrome

Empty sella syndrome can impact pituitary function in approximately 20 percent of cases. This condition can lead to deficiencies in one or more of the pituitary hormones. One of the most prevalent hormone deficiencies associated with empty sella syndrome is growth hormone deficiency; however, the effects of this deficiency on adults remain uncertain. Deficiencies in other pituitary-related hormones, such as thyroid-stimulating hormone and antidiuretic hormone, are uncommon in cases of empty sella syndrome.

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