The Presence of Inflammatory Markers in Keratoconus
Despite the presence of inflammatory markers in the tears of individuals diagnosed with keratoconus, some medical professionals question the classification of this condition as a non-inflammatory disease. Studies have shown that certain markers associated with inflammation can be found in the tears of these individuals.
However, scientists argue that keratoconus cannot be categorized as a pro-inflammatory disease due to the absence of new blood vessel formation or unusual multiplication, two key criteria for declaring a condition as inflammatory. These distinctive criteria are not observed in cases of keratoconus, leading to the classification of this condition as non-inflammatory.
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Genetics
The cause of keratoconus is mostly unknown, a condition known as idiopathic. However, there have been some cases where researchers have found a genetic factor involved. With the help of technological advancements like computerized videokeratoscopy, ophthalmologists have been able to identify patterns and map the inheritability of keratoconus. Moreover, through molecular genetics, chromosome 21 has been identified as a potential connection between keratoconus and Down Syndrome. It has also been discovered that the Keratoepithelin gene plays a role in eye-related dystrophies.