Evolution of Erythema Multiforme
The evolution of Erythema Multiforme can be traced back to the 1860s, when Ferdinand von Hebra became the first to document this condition. He aptly described it as “a temporary condition characterized by distinctive red papular skin lesions.” However, it wasn’t until the 1950s that the specific terms Erythema Multiforme Major and Erythema Multiforme Minor were officially introduced.
Causes of Erythema Multiforme
Erythema Multiforme (EM) can be caused by various factors including medications, infections, physical factors, and other diseases. The most common cause of EM Minor is the presence of Herpes Simplex Viruses 1 and 2. In fact, these viruses are responsible for up to 55% of all EM Major cases as well. Additionally, infections caused by bacteria, fungi, viruses, and parasites can also lead to this skin condition. Interestingly, certain medications used to treat these infections, such as over-the-counter pain medication, anticonvulsants, and antibiotics, can also trigger the development of Erythema Multiforme.