The Various Faces of Orthostatic Intolerance

OI in Chronic Fatigue Syndrome

Orthostatic intolerance (OI) is a prevalent symptom observed in individuals suffering from chronic fatigue syndrome (CFS). This condition is frequently associated with postural tachycardia syndrome (POTS) and neurally mediated hypotension (NMH). Research indicates that OI is more common among individuals with CFS than previously reported. Common symptoms of OI include dizziness and lightheadedness. Further findings reveal that these symptoms tend to worsen following physical exertion.


Understanding Neurally Mediated Hypotension (NMH)

Neurally Mediated Hypotension (NMH) is a condition characterized by chronic orthostatic intolerance due to a decrease in blood volume within the circulatory system and a defect in both the nervous and circulatory systems. The underlying issue begins in the nervous system, where the body’s ability to reflexively control the veins and arteries through the release of adrenaline is compromised. Despite the release of this hormone, the blood vessels fail to respond and constrict as they normally would. As a result, individuals with orthostatic hypotension may experience dizziness or lightheadedness upon standing, and in severe cases, may even faint.

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